Hepatotoxicity by herbs: a practical review of a neglected disease

Autores/as

  • Jean A. Donet Division of Gastroenterology and Hepatology, Miller School of Medicine, University of Miami. Coral Gables, Florida, United States.
  • Kay Sornmayura Division of Hepatology, Miller School of Medicine, University of Miami. Coral Gables, Florida, United States.
  • Matthew Gulau University of Miami. Coral Gables, Florida, United States
  • Eugene Schiff Division of Hepatology, Miller School of Medicine, University of Miami. Coral Gables, Florida, United States

DOI:

https://doi.org/10.47892/rgp.2016.364.60

Palabras clave:

Herbal medicine, Drug-induced liver injury, Epidemiology

Resumen

Herbs are commonly used worldwide for the treatment of various diseases, constituting a multi-billion dollar market. Unfortunately, hepatotoxicity induced by herbs is also common. The true incidence and prevalence are not known. There is need for more strict regulations andexperimental and pre-clinical studies regarding its efficacy and safety. There is no gold standard for the diagnosis of herbs-induced liver injury (HILI) and it constitutes a diagnostic challenge for the clinician, whereestablishing causality could be cumbersome. Clinical presentation varies from asymptomatic cases with mildly abnormal liver tests to fulminant liver failure requiring liver transplantation. In this review, we will discuss the epidemiology, clinical manifestations, challenges and diagnostic approach of HILI and will also present some exemplary cases from the University of Miami, Division of Hepatology.

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Publicado

09.01.2017

Cómo citar

1.
Donet JA, Sornmayura K, Gulau M, Schiff E. Hepatotoxicity by herbs: a practical review of a neglected disease. Rev Gastroenterol Peru [nternet]. 9 de enero de 2017 [citado 11 de octubre de 2024];36(4):350-3. isponible en: https://revistagastroperu.com/index.php/rgp/article/view/60

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