Severe gastroparesia associated with the use of GLP-1 receptor agonists for weight loss

Authors

DOI:

https://doi.org/10.47892/rgp.2024.441.1527

Keywords:

Obesity, GLP-1, Adverse effects

Abstract

Initially developed as medications for diabetes mellitus, GLP-1 agonists have 
popularity in the treatment of obesity and weight loss. The present case describes a 69-yearold woman with a history of peptic ulcer and use of NSAIDs, 
pain and oral intolerance refractory to conventional management, for which an 
digestive endoscopy was performed, diagnosing severe gastroparesis. Asking 
the story, revealed surreptitious use of semaglutide. She continued with 
and the symptoms resolved spontaneously. The present case report 
potential risks of the use of GLP-1 analogues in the context of endoscopy with sedation.

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References

Kalas MA, Dang TQ, Galura G, Alvarado L, Dwivedi AK, Deoker A, et al. Frequency of GLP-1 receptor agonists use in diabetic patients diagnosed with delayed gastric emptying and their demographic profile. Journal of Investigative Medicine. 2023;71(1):11-6. doi: 10.1136/jim-2022-002480.

Beti C, Stratmann B, Bokman G, Dreier J, Hauber M, Lee-Barkey YH, et al. Exenatide Delays Gastric Emptying in Patients with Type 2 Diabetes Mellitus but not in Those with Gastroparetic Conditions. Horm Metab Res. 2019;51(4):267-73. doi: 10.1055/a-0818-6374.

Robinson M, Davidson A. Aspiration under anaesthesia: risk assessment and decision-making. Anaesth Crit Care Pain Med. 2014:14(4):171-175. doi: 10.1093/bjaceaccp/mkt053.

Camilleri M, Kuo B, Nguyen L, Vaughn VM, Petrey J, Greer K, et al. ACG Clinical Guideline: Gastroparesis. Am J Gastroenterol. 2022;117(8):1197-220. doi: 10.14309/ajg.0000000000001874.

Goyal RK, Cristofaro V, Sullivan MP. Rapid gastric emptying in diabetes mellitus: Pathophysiology and clinical importance. J Diabetes Complications. 2019;33(11):107414. doi: 10.1016/j.jdiacomp.2019.107414.

Kittner SL, Talbott AL, Vishneski SR, Narbaiza J, Shields JS. Retained Gastric Contents After Adequate Fasting Associated with GLP-1 Receptor Agonist Use: A Report of 3 Cases. JBJS Case Connect. 2023;13(4). doi: 10.2106/JBJS.CC.23.00506.

Klein SR, Hobai IA. Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report. Can J Anesth. 2023;70(8):1394-6. doi: 10.1007/s12630-023-02440-3.

Stark JE, Cole JL, Ghazarian RN, Klass MJ. Impact of GlucagonLike Peptide-1 Receptor Agonists (GLP-1RA) on Food Content During Esophagogastroduodenoscopy (EGD). Ann Pharmacother. 2022;56(8):922-926. doi: 10.1177/10600280211055804.

Kobori T, Onishi Y, Yoshida Y, Tahara T, Kikuchi T, Kubota T, et al. Association of glucagon-like peptide-1 receptor agonist treatment with gastric residue in an esophagogastroduodenoscopy. J Diabetes Investig. 2023;14(6):767-773. doi: 10.1111/jdi.14005.

Gulak MA, Murphy P. Regurgitation under anesthesia in a fasted patient prescribed semaglutide for weight loss: a case report. Can J Anaesth. 2023;70(8):1397-1400. doi: 10.1007/s12630-023-02521-3.

Fujino E, Cobb KW, Schoenherr J, Gouker L, Lund E. Anesthesia Considerations for a Patient on Semaglutide and Delayed Gastric Emptying. Cureus. 2023;15(7):e42153. doi: 10.7759/cureus.42153.

Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: Application to Healthy Patients Undergoing Elective Procedures: An Updated Report by the American Society of Anesthesiologists Task Force on Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration. Anesthesiology. 2017;126(3):376-393. doi: 10.1097/ALN.0000000000001452.

Jones PM, Hobai IA, Murphy PM. Anesthesia and glucagon-like peptide-1 receptor agonists: proceed with caution! Can J Anaesth. 2023;70(8):1281-1286. doi: 10.1007/s12630-023-02550-y.

Hashash JG, Thompson CC, Wang AY. AGA Rapid Clinical Practice Update on the Management of Patients Taking GLP-1 Receptor Agonists Prior to Endoscopy: Communication. Clin Gastroenterol Hepatol. 2023:S1542-3565(23)00869-8. doi: 10.1016/j.cgh.2023.11.002.

Published

03/18/2024

How to Cite

1.
Chávez-Sánchez SA, Cedrón-Cheng HG. Severe gastroparesia associated with the use of GLP-1 receptor agonists for weight loss. Rev Gastroenterol Peru [nternet]. 2024 Mar. 18 [cited 2024 Dec. 21];44(1):71-4. vailable from: https://revistagastroperu.com/index.php/rgp/article/view/1527

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REPORTES DE CASOS

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