Fulminant acute liver failure secondary to severe dengue in a child: case report
DOI:
https://doi.org/10.47892/rgp.2024.442.1625Keywords:
Dengue, Liver failure, Renal insufficiency, Hepatic encephalopathy, ChildAbstract
Dengue is a common infectious disease in tropical areas such as Peru. This virus can cause underreported and potentially fatal complications such as acute liver failure. We report the case of a 7-year-old boy who presented with fever, headache, and abdominal pain. On ultrasound, we found hepatomegaly and labs severe thrombocytopenia and elevated transaminases. During hospitalization he was diagnosed with severe dengue and developed acute liver failure, kidney injury, and encephalopathy. Although intensive care management and assisted ventilation, he developed multiple organ dysfunctions with fluid refractoriness and capillary leak. Acute liver failure secondary to severe dengue is a rare complication with an unfavorable outcome.
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Vento S, Cainelli F. Acute liver failure in low-income and middle-income countries. Lancet Gastroenterol Hepatol. 2023;8(11):1035-45. doi: 10.1016/S2468-1253(23)00142-5.
Loi MV, Wang QY, Lee JH. Fluid management in children with severe dengue: a narrative review. Minerva Pediatr. 2023;75(1):49-61. doi: 10.23736/S2724-5276.22.06935-X.
Dogra S, Kumar K, Malhotra S, Jerath N, Sibal A. Acute Liver Failure in Dengue: A Common but Overlooked Entity in Pediatric Patients in Tropical Countries. J Pediatr Gastroenterol Nutr. 2023;76(2):149-53. doi: 10.1097/MPG.0000000000003646.
Prasad D, Bhriguvanshi A. Clinical Profile, Liver Dysfunction and Outcome of Dengue Infection in Children: A Prospective Observational Study. Pediatr Infect Dis J. 2020;39(2):97-101. doi: 10.1097/INF.0000000000002519.
World Health Organization. Dengue guidelines, for diagnosis, treatment, prevention and control: new edition [Internet]. Geneva: World Health Organization; 2009 [citado 20 de octubre de 2023]. p. 157. Disponible en: https://www.who.int/publications-detail-redirect/9789241547871
Pothapregada S, Kamalakannan B, Thulasingham M, Sampath S. Clinically Profiling Pediatric Patients with Dengue. J Glob Infect Dis. 2016;8(3):115-20. doi: 10.4103/0974-777X.188596.
Vega RM, Phumratanaprapin W, Phonrat B, Dhitavat J, Sutherat M, Choovichian V. Differences in Liver Impairment between Adults and Children with Dengue Infection. Am J Trop Med Hyg. 2016;94(5):1073-9. doi: 10.4269/ajtmh.15-0507.
Kye Mon K, Nontprasert A, Kittitrakul C, Tangkijvanich P, Leowattana W, Poovorawan K. Incidence and Clinical Outcome of Acute Liver Failure Caused by Dengue in a Hospital for Tropical Diseases, Thailand. Am J Trop Med Hyg. 2016;95(6):1338-44. doi: 10.4269/ajtmh.16-0374.
Laoprasopwattana K, Chaimongkol W, Pruekprasert P, Geater A. Acute Respiratory Failure and Active Bleeding Are the Important Fatality Predictive Factors for Severe Dengue Viral Infection. PLoS ONE. 2014;9(12):e114499. doi: 10.1371/journal. pone.0114499.
Alam R, Rukunuzzaman Md, Nahid KL. Hepatic involvement in childhood dengue infection. Egypt Liver J. 2023;13(1):45. doi: 10.1186/s43066-023-00281-9.
Fernando S, Wijewickrama A, Gomes L, Punchihewa CT, Madusanka SDP, Dissanayake H, et al. Patterns and causes of liver involvement in acute dengue infection. BMC Infect Dis. 2016;16:319. doi: 10.1186/s12879-016-1656-2.
Ferreira RAX, de Oliveira SA, Gandini M, Ferreira L da C, Correa G, Abiraude FM, et al. Circulating cytokines and chemokines associated with plasma leakage and hepatic dysfunction in Brazilian children with dengue fever. Acta Trop. 2015;149:138-47. doi: 10.1016/j.actatropica.2015.04.023
Leowattana W, Leowattana T. Dengue hemorrhagic fever and the liver. World J Hepatol. 2021;13(12):1968-76. doi: 10.4254/wjh.v13.i12.1968.
Sanjeet Bagcchi. Dengue outbreak in Peru affects adults and children. Lancet Infect Dis. 2023;23(9):e339. doi: 10.1016/S1473-3099(23)00229-3.
Laoprasopwattana K, Binsaai J, Pruekprasert P, Geater A. Prothrombin Time Prolongation was the Most Important Indicator of Severe Bleeding in Children with Severe Dengue Viral Infection. J Trop Pediatr. 2017;63(4):314-20. doi: 10.1093/tropej/fmw097.
Lodha A, Pillai A, Reddy P, Munshi N. Using first-contact serum ferritin to predict severe thrombocytopenia in dengue patients: determination and validation in independent cohorts. Infect Dis. 2022;54(6):425-30. doi: 10.1080/23744235.2022.2032823.
Setiorizaldi I, Tedjaningrum AA, Panggabean CG, Nangin E, Mahardhika JC, Daryanani CP. Pediatric Dengue Encephalopathy: A Review. Med Clin Update. 2022;1(1):5-7. doi: 10.58376/mcu.v1i1.5.
Sriphongphankul H, Liabsuetrakul T, Osatakul S. Clinical Outcomes of Children Diagnosed Dengue-Associated Acute Liver Failure with or without N-Acetylcysteine Treatment: A Retrospective Cohort Study. J Trop Pediatr. 2021;67(2):fmab039. doi: 10.1093/tropej/fmab039.
Tafere GG, Wondafrash DZ, Demoz FB. Repurposing of NAcetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure. Hepatic Med Evid Res. 2020;12:173-8. doi: 10.2147/HMER.S263840.
Vo LT, Do VC, Trinh TH, Vu T, Nguyen TT. Combined Therapeutic Plasma Exchange and Continuous Renal Replacement Therapy in Children With Dengue-Associated Acute Liver Failure and Shock Syndrome: Single-Center Cohort From Vietnam. Pediatr Crit Care Med. 2023;24(10):818-28. doi: 10.1097/PCC.0000000000003304.
Chikkala BR, Pandey Y, Acharya R, Sreekumar S, Dey R, Agarwal S, et al. Living Donor Liver Transplant for Dengue-Related Acute Liver Failure: A Case Report. Exp Clin Transplant. 2021;19(2):163-6. doi: 10.6002/ect.2020.0217.
Galante A, Adeyi O, Lau L, Humar A, Galvin Z, Selzner N, et al. Liver Transplantation for Acute Liver Failure Due to Dengue Fever. Hepatol. 2019;70(5):1863-5. doi: 10.1002/hep.30803.
Choudhary NS, Saigal S, Soin AS. Letter to the Editor: Liver Transplantation for Acute Liver Failure Because of Dengue Fever: First Successful Reported Case Worldwide. Hepatology. 2020;71(1):395-6. doi: 10.1002/hep.30869.
Saigal S, Choudhary NS, Saraf N, Kataria S, Mohanka R, Soin AS. Transmission of dengue virus from a donor to a recipient after living donor liver transplantation. Liver Transpl. 2013;19(12):1413-4. doi: 10.1002/lt.23755.
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Copyright (c) 2024 Jesús Domínguez-Rojas, Lizbeth Cabrera-Rojas, Tommy Prado-Gómez, Noé Atamari-Anahui
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