Successful management of hepatitis B and C coinfection: a case report

Authors

DOI:

https://doi.org/10.47892/rgp.2024.443.1732

Keywords:

Hepatitis B, Hepatitis C, Coinfection, Antiviral agents

Abstract

We report the case of a patient with chronic hepatitis B and C managed with direct-acting antivirals in an outpatient setting. Chronic hepatitis B was first treated with entecavir before initiating treatment for chronic hepatitis C. The patient achieved viral suppression for hepatitis B and sustained virological response for hepatitis C. As direct-acting antivirals become more available, healthcare practitioners should be familiar with managing patients with chronic coinfection.

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References

Radley A, Robinson E, Aspinall EJ, Angus K, Tan L, Dillon JF. A systematic review and meta-analysis of community and primary-care-based hepatitis C testing and treatment services that employ direct acting antiviral drug treatments. BMC Health Serv Res. 2019;19(1):765. doi: 10.1186/s12913-019-4635-7.

Shih Y-F, Liu C-J. Hepatitis C virus and hepatitis B virus coinfection. Viruses. 2020;12(7):741. doi: 10.3390/v12070741.

Wu J-C, Chen C-L, Hou M-C, Chen T-Z, Lee S-D, Lo K-J. Multiple viral infection as the most common cause of fulminant and subfulminant viral hepatitis in an area endemic for hepatitis B: Application and limitations of the polymerase chain reaction. Hepatology. 1994;19(4):836-40. doi: 10.1002/hep.1840190406.

Tyson GL, Kramer JR, Duan Z, Davila JA, Richardson PA, El-Serag HB. Prevalence and predictors of hepatitis B virus coinfection in a United States cohort of hepatitis C virus-infected patients. Hepatology. 2013;58(2):538-45. doi: 10.1002/hep.26400.

Vaccination coverage among adults in the United States, National Health Interview Survey, 2021 [Internet]. Atlanta: Centers for Disease Control and Prevention; 2023 [cited 2024 May 18]. Available from: https://www.cdc.gov/vaccines/imz-managers/coverage/adultvaxview/pubs-resources/vaccinationcoverage-adults-2021.html

Mavilia MG, Wu GY. HBV-HCV Coinfection: Viral Interactions, Management, and Viral Reactivation. J Clin Transl Hepatol. 2018;6(3):296-305. doi: 10.14218/JCTH.2018.00016.

Ma AT, Feld JJ. Hepatitis B reactivation with hepatitis C treatment: Bringing some clarity to the black box. Gastroenterology. 2018;154(4):795-8. doi: 10.1053/j.gastro.2018.02.005.

Terrault NA, Lok ASF, McMahon BJ, Chang K, Hwang JP, Jonas MM, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67(4):1560-99. doi: 10.1002/hep.29800.

American Association for the Study of Liver Diseases; Infectious Diseases Society of America. HCV Guidance: Recommendations for testing, managing, and treating hepatitis C [Internet]. AASLD-IDSA; 2014 [cited 2024 May 18]. Available from: http://www.hcvguidelines.org

Wang C, Ji D, Chen J, Shao Q, Li B, Liu J, et al. Hepatitis due to reactivation of hepatitis B virus in endemic areas among patients with hepatitis C treated with direct-acting antiviral agents. Clin Gastroenterol Hepatol. 2017;15(1):132-136. doi: 10.1016/j.cgh.2016.06.023.

Jiang XW, Ye JZ, Li YT, Li LJ. Hepatitis B reactivation in patients receiving direct-acting antiviral therapy or interferon-based therapy for hepatitis C: A systematic review and meta-analysis. World J Gastroenterol. 2018;24(28):3181-3191. doi: 10.3748/wjg.v24.i28.3181.

Simmons B, Saleem J, Hill A, Riley RD, Cooke GS. Risk of late relapse or reinfection with hepatitis C virus after achieving a sustained virological response: A systematic review and meta-analysis. Clin Infect Dis. 2016;62(6):683-694. doi: 10.1093/cid/civ948.

Weksler BB. Review article: the pathophysiology of thrombocytopenia in hepatitis C virus infection and chronic liver disease. Aliment Pharmacol Ther. 2007;26 Suppl 1:13-9. doi: 10.1111/j.1365-2036.2007.03512.x.

Soliman Z, El Kassas M, Elsharkawy A, Elbadry M, Hamada Y, ElHusseiny R, et al. Improvement of platelet in thrombocytopenic HCV patients after treatment with direct-acting antiviral agents and its relation to outcome. Platelets. 2020;32(3):383-90. doi: 10.1080/09537104.2020.1742313.

Rockey DC, Friedman SL. Fibrosis regression after eradication of hepatitis C virus: From bench to bedside. Gastroenterology. 2021;160(5):1502-1520.e1. doi: 10.1053/j.gastro.2020.09.065.

Cedrón-Cheng H, Siccha Sinti C, Tagle Arróspide M. Mejora del curso clínico de la cirrosis hepática por virus de hepatitis C posterior al tratamiento efectivo con antivirales de acción directa. Rev Gastroenterol Peru. 2021;41(4):257-60. doi: 10.47892/rgp.2021.414.1350.

Published

09/30/2024

How to Cite

1.
Freidenson-Bejar J, Bellido-Caparo A, Tagle M. Successful management of hepatitis B and C coinfection: a case report. Rev Gastroenterol Peru [nternet]. 2024 Sep. 30 [cited 2024 Nov. 21];44(3):301-4. vailable from: https://revistagastroperu.com/index.php/rgp/article/view/1732

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REPORTES DE CASOS

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