Rescue of a recurrence of rectal adenoma using the endoscopic intermuscular dissection technique
DOI:
https://doi.org/10.47892/rgp.2025.453.1916Keywords:
Colonoscopy, Rectal Neoplasms, Endoscopic Mucosal ResectionAbstract
Endoscopic intermuscular dissection (EID) emerges as an alternative for the treatment of patients with rectal lesions with suspected deep invasion or with extensive fibrosis which are not candidates for endoscopic submucosal dissection (ESD). In EID the dissection is performed between the inner (circular) and outer (longitudinal) layers of the muscularis propia. We present the case of a patient successfully treated with EID technique. 54-year-old female patient with a history sessile adenomatous lesion of the rectum of approximately 40 mm resected with conventional endoscopic mucosal resection technique. She presented a recurrence of the lesion on the prior resection scar. EID was performed on the scar of prior endoscopic resection, accessing and exposing the intermuscular plane. En bloc resection of the lesion was achieved with negative histological lateral and deep margins, fulfilling criteria for curative resection. Endoscopic resection techniques offer advantages over radical proctectomy, allowing preservation of anorectal function with lower morbidity and mortality. EID has shown effectiveness and safety in prospective studies and case report when ESD is not feasible due to technical limitations. However, further studies are required to evaluate the long-term efficacy and its comparison with other resection techniques.
Downloads
Metrics
References
Ministerio de Salud de Chile. Mortality statistics: Information [Internet]. Santiago: Ministerio de Salud; 2023 [citado el 10 de noviembre de 2023]. Disponible en: https://deis.minsal.cl
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-49. doi: 10.3322/caac.21660.
Zauber AG, Winawer SJ, O’Brien MJ, Lansdorp-Vogelaar I, van Ballegooijen M, Hankey BF, et al. Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths. Engl J Med. 2012;366(8):687-96. doi: 10.1056/NEJMoa1100370.
Ronnow CF, Arthursson V, Toth E, Krarup PM, Syk I, Thorlacius H. Lymphovascular Infiltration, Not Depth of Invasion, is the Critical Risk Factor of Metastases in Early Colorectal Cancer. Ann Surg. 2022;275(1):e148-54. doi: 10.1097/ SLA.0000000000003854.
Yasue C, Chino A, Takamatsu M, Namikawa K, Ide D, Saito S, et al. Pathological risk factors and predictive endoscopic factors for lymph node metastasis of T1 colorectal cancer: a singlecenter study of 846 lesions. J Gastroenterol. 2019;54(8):708- 17. doi: 10.1007/s00535-019-01564-y.
Toyonaga T, Ohara Y, Baba S, Takihara H, Nakamoto M, Orita H, et al. Peranal endoscopic myectomy (PAEM) for rectal lesions with severe fibrosis and exhibiting the muscle-retracting sign. Endoscopy. 2018;50(08):813-7. doi: 10.1055/a-0602-3905.
Liao S, Li B, Huang L, Qiu Q, Yang G, Ren J, et al. Endoscopic intermuscular dissection in the management of a rectal neuroendocrine tumor. Endoscopy. 2023;55(S 01):E977-9. doi: 10.1055/a-2139-4310.
Moons LMG, Bastiaansen BAJ, Richir MC, Hazen WL, Tuynman J, Elias SG, et al. Endoscopic intermuscular dissection for deep submucosal invasive cancer in the rectum: A new endoscopic approach. Endoscopy. 2022;54(10):993-8. doi: 10.1055/a1748-8573.
Dang H, Hardwick JCH, Boonstra JJ. Endoscopic intermuscular dissection with intermuscular tunneling for local resection of rectal cancer with deep submucosal invasion. VideoGIE. 2022;7(8):273-277. doi: 10.1016/j.vgie.2022.02.012.
Berger NF, Sylla P. The Role of Transanal Endoscopic Surgery for Early Rectal Cancer. Clin Colon Rectal Surg. 2022;35(2):113- 21. doi: 10.1055/s-0041-1742111.
Yamada M, Saito Y, Takamaru H, Sasaki H, Yokota T, Matsuyama Y, et al. Long-term clinical outcomes of endoscopic submucosal dissection for colorectal neoplasms in 423 cases: A retrospective study. Endoscopy. 2017;49(3):233-42. doi: 10.1055/s-0042-124366.
Watanabe D, Toyonaga T, Ooi M, Yoshizaki T, Ohara Y, Tanaka S, et al. Clinical outcomes of deep invasive submucosal colorectal cancer after ESD. Surg Endosc. 2018;32(4):2123-30. doi: 10.1007/s00464-017-5910-5.
Nishizawa T, Ueda T, Ebinuma H, Toyoshima O, Suzuki H. LongTerm Outcomes of Endoscopic Submucosal Dissection for Colorectal Epithelial Neoplasms: A Systematic Review. Cancers (Basel). 2022 Dec 30;15(1):239. doi: 10.3390/cancers15010239.
Eid Y, Alves A, Lubrano J, Menahem B. Does previous transanal excision for early rectal cancer impair surgical outcomes and pathologic findings of completion total mesorectal excision? Results of a systematic review of the literature. J Visc Surg. 2018;155(6):445-52. doi: 10.1016/j.jviscsurg.2018.03.008.
Tribonias G, Komeda Y, Leontidis N, Anagnostopoulos G, Palatianou M, Mpellou G, et al. Endoscopic intermuscular dissection (EID) for removing early rectal cancers and benign fibrotic rectal lesions. Tech Coloproctol. 2023;27(12):1393-400. doi: 10.1007/s10151-023-02862-7.
Ichita C, Sasaki A, Kawachi J, Hirose H, Kamiishi H, Kubota J, et al. Endoscopic intermuscular dissection for a lower rectal gastrointestinal stromal tumor. Endoscopy. 2023;55:E258-9. doi: 10.1055/a-1974-8823.
Dang H, Verhoeven DA, Basiliya K, Boonstra JJ. Endoscopic intermuscular dissection of early anal cancer. Endoscopy. 2024;56(S 01):E472-3. doi: 10.1055/a-2321-9527.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Gonzalo Latorre, Javier Perez-Valenzuela, Felipe Silva, Antonio Pausin, Antonio Mercandino, José Tomás Peña, Javiera Torres, Felipe Bellolio, Andrés Donoso

This work is licensed under a Creative Commons Attribution 4.0 International License.
Revista de Gastroenterología del Perú by Sociedad Peruana de Gastroenterología del Perú is licensed under a Licencia Creative Commons Atribución 4.0 Internacional..
Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes:
- Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista.
- Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
- Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) antes y durante el proceso de envío, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).








2022