Evaluation of frequency of autoimmune hepatitis autoantibodies in children with type 1 diabetes

Autores/as

  • Naser Honar Shiraz University of Medical Sciences
  • Zohreh Karamizadeh Shiraz University of Medical Sciences
  • Majid-Vares Vazirian Shiraz University of Medical Sciences
  • Keramatallah Jahanshahi Shiraz University of Medical Sciences
  • Ali Manouchehri Shiraz University of Medical Sciences
  • Seyed Mohsen Dehghani Shiraz University of Medical Sciences
  • Hazhir Javaherizadeh Ahvaz Jundishapur University of Medical Sciences

DOI:

https://doi.org/10.47892/rgp.2019.394.997

Palabras clave:

Antibodies, antinuclear, Autoantibodies, Autoimmune diseases, Hepatitis

Resumen

Background: Diabetes mellitus type 1 (T1DM) is one of the childhood diseases with growing prevalence. Various accompanying autoimmune diseases were seen with type 1 diabetes. The most common autoimmune diseases with T1DM are autoimmune thyroiditis and celiac disease. In some reports, autoimmune hepatitis has been reported in association with DM-1. Objectives: The aim of this study was to evaluate autoimmune hepatitis autoantibodies in children with T1DM. Materials and methods: In this crosssectional study, 202 children with T1DM were evaluated (47.5% were males and 52.5% were girls). Liver enzymes, autoimmune

hepatitis related autoantibodies such as anti-nuclear antibodies (ANA), anti-smooth muscle (ASMA) and anti liver and kidney microsomal antibodies (LKM-1) were measured. Liver ultrasound was done for participants and biopsy of liver was taken for children with increased echogenicity of the liver, hepatomegaly or elevated liver enzymes. Results analyzed by statistical software spss-16, Descriptive statistics and chi-square test, paired T-TEST. Level of less than 5% was considered statistically significant. Results: In 6 patients ANA and in 4 patients (2%) ASMA was positive,1 patient was ASMA positive but ANA negative. None of the patients were Anti LKM-1 positive. 3 patients had positive ANA and ASMA, and increased liver echogenicity on ultrasound simultaneously. Histological evaluation was showed that 2 patients had findings in favor of autoimmune hepatitis. Conclusion: Auto antibodies were positive in 10 cases. ANA was positive in 6 (2.97%) of all cases. ASMA was positive in 4 (1.98%) cases. Increased echogenicity was found in 3 cases. Histological evaluation showed 2 patients had biopsy confirmed autoimmune hepatitis. AIH-2 was not seen among our cases.

Descargas

Los datos de descargas todavía no están disponibles.

Métricas

Cargando métricas ...

Descargas

Publicado

16.02.2020

Cómo citar

1.
Honar N, Karamizadeh Z, Vazirian M-V, Jahanshahi K, Manouchehri A, Mohsen Dehghani S, Javaherizadeh H. Evaluation of frequency of autoimmune hepatitis autoantibodies in children with type 1 diabetes. Rev Gastroenterol Peru [nternet]. 16 de febrero de 2020 [citado 15 de junio de 2024];39(4):344-7. isponible en: https://revistagastroperu.com/index.php/rgp/article/view/997

Número

Sección

ARTÍCULOS ORIGINALES

Artículos más leídos del mismo autor/a