Effect of sequential therapy on treatment of Helicobacter pylori infection in children

Autores/as

  • Seyed Mohsen Dehghani Gastroenterohepatology Research Center, Nemazee Teaching Hospital, Shiraz University of Medical Sciences. Shiraz, Iran.
  • Afsaneh Nazari Department of Pediatrics, Nemazee Teaching Hospital, Shiraz University of Medical Sciences. Shiraz, Iran.
  • Hazhir Javaherizadeh Alimenatry Tract Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

DOI:

https://doi.org/10.47892/rgp.2018.382.882

Palabras clave:

Helicobacter pylori, Terapéutica, Eradication

Resumen

Background: Helicobacter pylori infection which plays a major role in the etiology of chronic gastritis and duodenal ulcers in children and adults is one of the commonest chronic infection worldwide. Cure of the infection leads to healing of gastric inflammation and prevention of peptic ulcer. Objective: The aim of this study was to evaluate the efficacy of the sequential therapy for treatment of Helicobacter pylori infection. Materials and methods: In this study, 40 children with symptoms of H. Pylori that the infection was proved by endoscopy and biopsy and rapid urease test (UBT) were enrolled, and received sequential therapy (Lansoprazol, Amoxicillin) for 5 days and (Lansoprazol, Metronidazole and Clarithromycin) for next 5 days. The eradication rate of therapy was evaluated by stool antigen test 6 weeks after completion of therapy. This study was carried out in Pediatric Gastroenterology Clinic of Shiraz University of Medical Sciences, Shiraz, Iran. This study was approved by ethic committee of Shiraz University of Medical Sciences. Results: Forty children with mean age of (10.8±4 years) were evaluated. The most common symptom on first admission was epigastric pain (82.5%), with mean duration of symptoms (16±14.5 month). The most common endoscopic findings was redness and erosion of the antrum (55%) and the most pathologic findings was chronic gastritis (77.5%). The most drug adverse effect was nausea (22.5%). The eradication rate of sequential therapy was 82.5%. Conclusion: Eradication rate of sequential therapy was 82.5% among our cases.

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Publicado

10.08.2018

Cómo citar

1.
Mohsen Dehghani S, Nazari A, Javaherizadeh H. Effect of sequential therapy on treatment of Helicobacter pylori infection in children. Rev Gastroenterol Peru [nternet]. 10 de agosto de 2018 [citado 15 de junio de 2024];38(2):128-30. isponible en: https://revistagastroperu.com/index.php/rgp/article/view/882

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