Case report: uveal melanoma with gastric metastases

Authors

DOI:

https://doi.org/10.47892/rgp.2025.452.1826

Keywords:

Uveal Melanoma, Neoplasm Metastasis, Stomach Neoplasms

Abstract

Uveal melanoma is the most common ocular cancer in adults, originating from melanocytes in the uvea. Although rare, its high metastatic potential, primarily to the liver, poses a significant challenge to patient prognosis. Gastric metastasis, though infrequent, may indicate advanced disease, with an incidence of up to 60% in post-mortem studies. We present the case of a 47-year-old patient with a history of uveal melanoma who developed gastric and hepatic metastases, as well as brain lesions, ultimately leading to her death within a short period.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Krantz BA, Dave N, Komatsubara KM, Marr BP, Carvajal RD. Uveal melanoma: epidemiology, etiology, and treatment of primary disease. Clin Ophthalmol. 2017;11:279-289. doi: 10.2147/OPTH.S89591.

Reggiani HC, Pongeluppi ACA, Ferreira VFMM, Felix IP, de Oliveira Campoli PM. Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review. Clin Endosc. 2022;55(4):507-515. doi: 10.5946/ce.2022.035.

Switzer B, Puzanov I, Skitzki JJ, Hamad L, Ernstoff MS. Managing Metastatic Melanoma in 2022: A Clinical Review. JCO Oncol Pract. 2022;18(5):335-351. doi: 10.1200/OP.21.00686.

De Palma GD, Masone S, Rega M, Simeoli I, Donisi M, Addeo P, et al. Metastatic tumors to the stomach: clinical and endoscopic features. World J Gastroenterol. 2006;12(45):7326- 8. doi: 10.3748/wjg.v12.i45.7326.

Kobayashi O, Murakami H, Yoshida T, Cho H, Yoshikawa T, Tsuburaya A, et al. Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center. World J Surg. 2004;28(6):548- 51. doi: 10.1007/s00268-004-7216-8.

Namikawa T, Hanazaki K. Clinicopathological features and treatment outcomes of metastatic tumors in the stomach. Surg Today. 2014;44(8):1392-9. doi: 10.1007/s00595-013-0671-9.

Kim GH, Ahn JY, Jung HY, Park YS, Kim MJ, Choi KD, et al. Clinical and Endoscopic Features of Metastatic Tumors in the Stomach. Gut Liver. 2015;9(5):615-22. doi: 10.5009/gnl14032.

Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V. Ocular melanoma: an overview of the current status. Int J Clin Exp Pathol. 2013;6(7):1230-44.

Singh AD, Bergman L, Seregard S. Uveal melanoma: epidemiologic aspects. Ophthalmol Clin North Am. 2005;18(1):75-84, viii. doi: 10.1016/j.ohc.2004.07.002.

Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD. Metastatic disease from uveal melanoma: treatment options and future prospects. Br J Ophthalmol. 2017;101(1):38-44. doi: 10.1136/bjophthalmol-2016-309034.

Shields CL, Kaliki S, Furuta M, Fulco E, Alarcon C, Shields JA. American Joint Committee on Cancer classification of posterior uveal melanoma (tumor size category) predicts prognosis in 7731 patients. Ophthalmology. 2013;120(10):2066-71. doi: 10.1016/j.ophtha.2013.03.012.

Collaborative Ocular Melanoma Study Group.. Assessment of metastatic disease status at death in 435 patients with large choroidal melanoma in the Collaborative Ocular Melanoma Study (COMS): COMS report no. 15. Arch Ophthalmol. 2001;119(5):670-6. doi: 10.1001/archopht.119.5.670.

Gragoudas ES, Egan KM, Seddon JM, Glynn RJ, Walsh SM, Finn SM, Munzenrider JE, Spar MD. Survival of patients with metastases from uveal melanoma. Ophthalmology. 1991;98(3):383-9; discussion 390. doi: 10.1016/s0161- 6420(91)32285-1.

Singh AD, Borden EC. Metastatic uveal melanoma. Ophthalmol Clin North Am. 2005;18(1):143-50, ix. doi: 10.1016/j. ohc.2004.07.003.

Iconomou TG, Tsoutsos D, Frangia K, Gogas H, Papadopoulos S, Georgountzos V, Ioannovich J. Malignant melanoma of the stomach presenting with an unknown primary lesion. Eur J Plast Surg. 2003;26:153-155. doi: 10.1007/s00238-003- 0497-6

Blecker D, Abraham S, Furth EE, Kochman ML. Melanoma in the gastrointestinal tract. Am J Gastroenterol. 1999;94(12):3427- 33. doi: 10.1111/j.1572-0241.1999.01604.x.

Wong K, Serafi SW, Bhatia AS, Ibarra I, Allen EA. Melanoma with gastric metastases. J Community Hosp Intern Med Perspect. 2016;6(4):31972. doi: 10.3402/jchimp.v6.31972.

Serrao EM, Costa AM, Ferreira S, McMorran V, Cargill E, Hough C, et al. The diferent faces of metastatic melanoma in the gastrointestinal tract. Insights Imaging. 2022;13(1):161. doi: 10.1186/s13244-022-01294-5.

Othman AE, Eigentler TK, Bier G, Pfannenberg C, Bösmüller H, Thiel C, et al. Imaging of gastrointestinal melanoma metastases: Correlation with surgery and histopathology of resected specimen. Eur Radiol. 2017;27(6):2538-2545. doi: 10.1007/s00330-016-4625-7.

Tarlan B, Kıratlı H. Uveal Melanoma: Current Trends in Diagnosis and Management. Turk J Ophthalmol. 2016;46(3):123-137. doi: 10.4274/tjo.37431.

Published

06/30/2025

How to Cite

1.
Blasco C, Miranda C, Morínigo S, Vallejos M, Caballero A. Case report: uveal melanoma with gastric metastases. Rev Gastroenterol Peru [nternet]. 2025 Jun. 30 [cited 2026 Jan. 30];45(2):198-201. vailable from: https://revistagastroperu.com/index.php/rgp/article/view/1826

Issue

Section

REPORTES DE CASOS

Most read articles by the same author(s)