Lymphocytic esophagitis as a cause of dysphagia: a case report and brief literature review
DOI:
https://doi.org/10.47892/rgp.2026.461.2089Keywords:
Dysphagia, Esophagitis, EndoscopyAbstract
Lymphocytic esophagitis (LyE) is a chronic inflammatory condition of the esophagus with a prevalence of ~0.1% among esophageal biopsies. The main clinical manifestations are dysphagia, heartburn, and chest pain; some endoscopic findings includes rings, strictures, and furrows. A 63-year-old woman with Sjögren syndrome and treated hypothyroidism presented with a 1-year history of progressive solid-food dysphagia and 4-kg weight loss. Endoscopy and a barium esophagogram revealed a proximal esophageal web, which was treated with endoscopic dilation. A follow-up esophagogastroduodenoscopy showed esophageal rings and luminal narrowing. Biopsies confirmed LyE. She was treated with esomeprazole with good clinical response. LyE is a recently described entity in which clinicopathologic correlations are not always straightforward. Given overlap in symptoms and endoscopic features, eosinophilic esophagitis is the principal differential diagnosis. Management options include proton-pump inhibitors, swallowed topical corticosteroids, and esophageal dilation for fixed strictures. Clear, evidence-based clinical guidelines are still lacking.
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Mastracci L, Grillo F, Parente P, Unti E, Battista S, Spaggiari P, et al. Non gastro-esophageal reflux disease related esophagitis: An overview with a histologic diagnostic approach. Pathologica. 2020;112(3):128-37. doi: 10.32074/1591-951X-156.
Panarelli NC. Other Forms of Esophagitis: It Is Not Gastroesophageal Reflux Disease, So Now What Do I Do? Surg Pathol Clin. 2017;10(4):765-79. doi: 10.1016/j. path.2017.07.001.
Rubio CA, Sjödahl K, Lagergren J. Lymphocytic esophagitis: a histologic subset of chronic esophagitis. Am J Clin Pathol. 2006;125(3):432-7.
Cohen S, Saxena A, Waljee AK, Piraka C, Purdy J, Appelman H, et al. Lymphocytic esophagitis: A diagnosis of increasing frequency. J Clin Gastroenterol. 2012;46(10):828-32. doi: 10.1097/MCG.0b013e3182500de8.
Haque S, Genta RM. Lymphocytic oesophagitis: Clinicopathological aspects of an emerging condition. Gut. 2012;61(8):1108-14. doi: 10.1136/gutjnl-2011-301014.
Zaver HB, Ghoz H, Malviya BJ, Brahmbhatt B, Palmer WC, Lacy BE, et al. Lymphocytic Esophagitis: Assessing Risk Factors and Clinical Outcomes. Dig Dis Sci. 2021;66(11):3976-84. doi: 10.1007/s10620-020-06706-4.
Rouphael C, Gordon IO, Thota PN. Lymphocytic esophagitis: Still an enigma a decade later. World J Gastroenterol. 2017;23(6):949-56. doi: 10.3748/wjg.v23.i6.949.
Pittman ME. Lymphocytic Esophagitis: Current Understanding and Controversy. Am J Surg Pathol. 2022;46(1):e55-63. doi: 10.1097/PAS.0000000000001667.
Hussein M, Mitchison M, Sweis R. Lymphocytic oesophagitis: diagnosis and management. Clin Med (Lond). 2023;23(6):540- 4. doi: 10.7861/clinmed.2023-0440.
Pasricha S, Gupta A, Reed CC, Speck O, Woosley JT, Dellon ES. Lymphocytic Esophagitis: An Emerging Clinicopathologic Disease Associated with Dysphagia. Dig Dis Sci. 2016;61(10):2935-41. doi: 10.1007/s10620-016-4230-2.
Habbal M, Scaffidi MA, Rumman A, Khan R, Ramaj M, Al-Mazroui A, et al. Clinical, endoscopic, and histologic characteristics of lymphocytic esophagitis: a systematic review. Esophagus. 2019;16(2):123-32. doi: 10.1007/s10388-018- 0649-1.
Patil DT, Hammer S, Langer R, Yantiss RK. Lymphocytic esophagitis: An update on histologic diagnosis, endoscopic findings, and natural history. Ann N Y Acad Sci. 2018;1434(1):185-91. doi: 10.1111/nyas.13710.
Lisovsky M. Inflammatory conditions of the esophagus: an update. Ann N Y Acad Sci. 2020;1481(1):5-10. doi: 10.1111/ nyas.14450.
Visaggi P, Savarino E, Corso G Del, Herlihy N, Ghisa M, Dunn JM, et al. Clinical Characteristics, Endoscopic Findings, and Treatment Outcomes in Lymphocytic Esophagitis Compared With Eosinophilic Esophagitis. Am J Gastroenterol. 2025;120(2):469-72. doi: 10.14309/ajg.0000000000003046.
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Copyright (c) 2026 Javier Perez-Valenzuela, Manuel Barrera, María Francisca Vergara, Javier Chahuán
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