Comparison of two maneuvers to identify Carnett's sign in patients with chronic abdominal pain. Randomized controlled clinical trial
DOI:
https://doi.org/10.47892/rgp.2025.451.1811Keywords:
Chronic abdominal pain, ACNES, Carnett's sign, LidocaineAbstract
Introduction: Chronic abdominal pain (CAP) is a challenge in daily consultation. The most frequent cause is anterior cutaneous nerve entrapment syndrome (ACNES), which is diagnosed when the Carnett sign is positive. There are two ways to identify the Carnett sign: elevating the head and trunk or elevating the lower extremities. To date, these two ways of looking for the Carnett sign have not been compared. Objective: To compare the effectiveness of the two maneuvers to identify the Carnett sign, evaluate the effectiveness of infiltration of the tender points with 2% lidocaine, and estimate the cost of examinations before diagnosis. Material and methods: Randomized controlled study. Results: 1320 patients were included and 660 patients were randomly assigned to group A: elevation of the head and trunk and 660 to group B: elevation of the lower extremities. Both maneuvers were similarly effective in identifying the Carnett sign. Infiltration of the points produced immediate relief in most patients. The costs of different studies before definitive diagnosis were approximately US$ 861 000 (dollars) versus US$ 66.00, which would be equivalent to 7.6% of the expenses incurred for tests performed before diagnosis. Conclusion: The two ways of exploring the Carnett sign have similar efficacy. Infiltration with 2% lidocaine produced rapid and significant improvement of pain with minimal side effects. Not knowing the Carnett sign increases health costs.
Downloads
Metrics
References
Otero Regino W, Martínez Rodríguez E, Lúquez Mindiola A. The Cost Of Ignoring Carnett´s Sign: A Case Report and Literature Review. Rev Colomb Gastroenterol. 2017;32(1):75- 81. doi: 10.22516/25007440.134.
Otero W, Ruiz X, Otero E, Gómez M, Pineda L. F, Arbeláez V. Dolor crónico de la pared abdominal: una entidad poco reconocida con gran impacto en la práctica médica. Rev Colomb Gastroenterol. 2007;22(4):261-271.
Brenner DM, Brandt LJ, Fenster M, Hamilton MJ, Kamboj AK, Oxentenko AS, et al. Rare, Overlooked, or Underappreciated Causes of Recurrent Abdominal Pain: A Primer for Gastroenterologists. Clin Gastroenterol Hepatol. 2023;21(2):264-79. doi: 10.1016/j.cgh.2022.09.022.
Boelens OB, Scheltinga MR, Houterman S, Roumen RM Randomized clinical trial of trigger point infiltration with lidocaine to diagnose anterior cutaneous nerve entrapment syndrome. Br J Surg. 2013;100(2):217-21. doi: 10.1002/ bjs.8958.
Oor JE, Ünlü Ç, Hazebroek EJ A systematic review of the treatment for abdominal cutaneous nerve entrapment syndrome. Am J Surg. 2016;212(1):165-74. doi: 10.1016/j. amjsurg.2015.12.013
van der Graaf T, Verhagen PC, Kerver AL, Kleinrensink GJ. Surgical anatomy of the 10th and 11th intercostal, and subcostal nerves: prevention of damage during lumbotomy. J Urol 2011;186(2):579–583. doi: 10.1016/j.juro.2011.03.120.
Scheltinga MR, Roumen RM. Anterior cutaneous nerve entrapment syndrome (ACNES). Hernia. 2018;22(3):507-516. doi: 10.1007/s10029-017-1710-z.
Lindsetmo RO, Stulberg J. Chronic abdominal wall pain- -a diagnostic challenge for the surgeon. Am J Surg. 2009;198(1):129-34. doi: 10.1016/j.amjsurg.2008.10.027.
Applegate WV, Buckwalter NR. Microanatomy of the structures contributing to abdominal cutaneous nerve entrapment syndrome. J Am Board Fam Pract. 1997;10:329-332.
Applegate WV. Abdominal cutaneous nerve entrapment syndrome. Surgery. 1972;71(1):118-24.
Carnett JB. Intercostal neuralgia as a cause of abdominal pain and tenderness. Surg Gyn Obstet. 1926;42:625-632.
Maatman RC, Papen-Botterhuis NE, Scheltinga MRM, Roumen RMH. Lateral Cutaneous lateral cutaneous nerve entrapment syndrome (LACNES) (Nerve Entrapment Syndrome (LACNES): A previously unrecognized cause of intractable flank pain. Scand J Pain. 2017; 17:211-217. doi: 10.1016/j.sjpain.2017.10.007.
Maatman RC, Boelens OB, Scheltinga MRM, Roumen RMH. Chronic localized back pain due to entrapment of cutaneous branches of posterior rami of the thoracic nerves (POCNES): a case series on diagnosis and management. J Pain Res. 2019; 12:715-723. doi: 10.2147/JPR.S178492.
Otsuka Y, Ishizuka K, Harada Y, Harada T, Shikino K, Shiraishi Y, et al. Three Subtypes of Cutaneous Nerve Entrapment Syndrome: A Narrative Review. Intern Med. 2024;63(16):2231- 2239. doi: 10.2169/internalmedicine.2927-23.
Kamboj AK, Hoversten P, Oxentenko AS. Chronic abdominal wall pain: a common yet overlooked etiology of chronic abdominal pain. Mayo Clin Proc. 2019;94:139-144. doi: 10.1016/j.mayocp.2018.09.018.
Scheltinga MR, Roumen RM. Anterior cutaneous nerve entrapment syndrome (ACNES). Hernia. 2018;22(3):507-516. doi: 10.1007/s10029-017-1710-z.
Glissen Brown JR, Bernstein GR, Friedenberg FK, Ehrlich AC. Chronic Abdominal Wall Pain: An Under-Recognized Diagnosis Leading to Unnecessary Testing. J Clin Gastroenterol. 2016;50(10):828-835. doi: 10.1097/MCG.0000000000000636.
Costanza CD, Longstreth GF, Liu AL. Chronic abdominal wall pain: clinical features, health care costs, and long-term outcome. Clin Gastroenterol Hepatol. 2004;2(5):395-9. doi: 10.1016/s1542-3565(04)00124-7.
Walsh CM, Umar SB, Ghassemi S, Aihara H, Anand GS, Cassani L, et al. Colonoscopy core curriculum. Gastrointest Endosc. 2021;93(2):297-304. doi: 10.1016/j.gie.2020.06.054.
Walsh CM. In-training gastrointestinal endoscopy competency assessment tools: types of tools, validation and impact. Best Pract Res Clin Gastroenterol. 2016;30(3):357-74. doi: 10.1016/j. bpg.2016.04.001.
Matharoo M, Haycock A, Sevdalis N, Thomas-Gibson S. Endoscopic non-technical skills team training: the next step in quality assurance of endoscopy training. World J Gastroenterol. 2014;20(46):17507-15. doi: 10.3748/wjg.v20.i46.17507.
Hitchins CR, Metzner M, Edworthy J, Ward C. Non-technical skills and gastrointestinal endoscopy: a review of the literature. Frontline Gastroenterol. 2018;9(2):129-134. doi: 10.1136/ flgastro-2016-100800.
Thomson H, Francis DM. Abdominal-wall tenderness: A useful sign in the acute abdomen. Lancet. 1977;2(8047):1053-4. doi: 10.1016/s0140-6736(77)91885-2.
Graff LG 4th, Robinson D. Abdominal pain and emergency department evaluation. Emerg Med Clin North Am. 2001;19(1):123-36. doi: 10.1016/s0733-8627(05)70171-1.
Have TT, Geffen STV, Zwaans WAR, Maatman RC, Boelens OBA, Steegers MAH, et al. Pulsed radiofrequency or surgery for anterior cutaneous nerve entrapment syndrome: Longterm results of a randomized controlled trial. Pain Pract. 2024;24(2):288-295. doi: 10.1111/papr.13305.
Boelens OB, Scheltinga MR, Houterman S, Roumen RM. Management of anterior cutaneous nerve entrapment syndrome in a cohort of 139 patients. Ann Surg. 2011;254(6):1054-8. doi: 10.1097/SLA.0b013e31822d78b8.
Mayorga-Ortiz J, Otero Regino W, Alzate Granados J, Marulanda Hernández H. Evaluation of sustained responses to infiltration of local anesthetic in patients with chronic abdominal wall pain. Rev Colomb Gastroenterol. 2020;35(2):159-64. doi: 10.22516/25007440.364.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 William Otero Regino, Gilberto Jaramillo Trujillo, Lina Otero Parra, Hernando Marulanda Fernández, Juan Sebastián Frías, Julián Cardona González, Elder Otero Ramos

This work is licensed under a Creative Commons Attribution 4.0 International License.
Revista de Gastroenterología del Perú by Sociedad Peruana de Gastroenterología del Perú is licensed under a Licencia Creative Commons Atribución 4.0 Internacional..
Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes:
- Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista.
- Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
- Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) antes y durante el proceso de envío, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).








2022